At moderate doses, ketamine can produce a strange state of consciousness where the self can feel detached or estranged from the body and surroundings and the boundary between one's own body and someone else's can become blurred. While it is possible to feel disoriented or confused in this state, and one may experience passing anxiety, this sense of detachment tends to "numb" the user somewhat to threatening situations.
At higher doses, ketamine's dissociative properties can produce strong psychedelic experiences that leave the user physically incapacitated and more or less unresponsive to their environment. This can obviously be dangerous in an unsafe setting, and people using ketamine to facilitate rape
is not unheard of in or outside the chemsex community.
As long as one avoids incapacitating doses and/or is in a safe environment, ketamine is a relatively safe drug with a low risk of acute harms other than stumbling and falling. However, it is important to note that ketamine should not be combined with alcohol or GHB/GBL, as this can lead to severe dizziness, disorientation and vomiting with the risk of choking.